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Serotype-specific restriction of wild-type Adenoviruses by the cellular Mre11-Rad50-Nbs1 complex
During viral replication in the nucleus, the DNA genomes of adenoviruses are accessible to cellular DNA-binding proteins. Human adenovirus type 5 (Ad5) targets the cellular Mre11-Rad50-Nbs1 complex (MRN) to evade detection by the DNA damage response (DDR). Ad5 mutants that cannot target MRN have red...
Tallennettuna:
| Julkaisussa: | Virology |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5911183/ https://ncbi.nlm.nih.gov/pubmed/29547809 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.02.023 |
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