Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts

LMNA encodes the A-type lamins that are part of the nuclear scaffold. Mutations in LMNA can cause a variety of disorders called laminopathies, including Hutchinson-Gilford progeria syndrome (HGPS), atypical Werner syndrome, and Emery-Dreifuss muscular dystrophy. Previous work has shown that treatmen...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: DuBose, Amanda J., Lichtenstein, Stephen T., Petrash, Noreen M., Erdos, Michael R., Gordon, Leslie B., Collins, Francis S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910873/
https://ncbi.nlm.nih.gov/pubmed/29581305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1802811115
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