CD1b tetramers identify T-cells that recognize natural and synthetic diacylated sulfoglycolipids from Mycobacterium tuberculosis

Mycobacterial cell wall lipids bind the conserved CD1 family of antigen-presenting molecules and activate T-cells via their T-cell receptors (TCRs). Sulfoglycolipids (SGLs) are uniquely synthesized by Mycobacterium tuberculosis, but tools to study SGL-specific T-cells in humans are lacking. We desig...

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Publicat a:Cell Chem Biol
Autors principals: James, Charlotte A., Yu, Krystle K. Q., Gilleron, Martine, Prandi, Jacques, Yedulla, Vijayendar R., Moleda, Zuzanna Z., Diamanti, Eleonora, Khan, Momin, Aggarwal, Varinder K., Reijneveld, Josephine F., Reinink, Peter, Lenz, Stefanie, Emerson, Ryan O., Scriba, Thomas J., Souter, Michael N. T., Godfrey, Dale I., Pellicci, Daniel G., Moody, D. Branch, Minnaard, Adriaan J., Seshadri, Chetan, Van Rhijn, Ildiko
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5910231/
https://ncbi.nlm.nih.gov/pubmed/29398561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.01.006
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