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Enantioselective Synthesis of Pyrrolopyrimidine Scaffolds through Cation-Directed Nucleophilic Aromatic Substitution
The catalytic enantioselective synthesis of 3-aryl-substituted pyrrolopyrimidines (PPYs), a common motif in drug discovery, is achieved through a kinetic resolution via quaternary ammonium salt-catalyzed nucleophilic aromatic substitution (S(N)Ar). Both enantioenriched products and starting material...
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| Veröffentlicht in: | Org Lett |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5909700/ https://ncbi.nlm.nih.gov/pubmed/29561161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.8b00579 |
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