Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury

AIMS: A longevity gene, Sirtuin 1 (SIRT1) and energy sensor AMP-activated protein kinase (AMPK) have common activators such as caloric restriction, oxidative stress, and exercise. The objective of this study is to characterize the role of cardiomyocyte SIRT1 in age-related impaired ischemic AMPK act...

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Gepubliceerd in:Cardiovasc Res
Hoofdauteurs: Wang, Lin, Quan, Nanhu, Sun, Wanqing, Chen, Xu, Cates, Courtney, Rousselle, Thomas, Zhou, Xinchun, Zhao, Xuezhong, Li, Ji
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2018
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909650/
https://ncbi.nlm.nih.gov/pubmed/29409011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvy033
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