Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress

Pyruvate dehydrogenase (PDH) plays a key role in aerobic energy metabolism and occupies a central crossroad between glycolysis and the tricarboxylic acid cycle. We generated inducible cardiac-specific PDH E1α knockout (CreER(T2)-PDH(flox/flox)) mice that demonstrated a high mortality rate. It was hy...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Sun, Wanqing, Quan, Nanhu, Wang, Lin, Yang, Hui, Chu, Dongyang, Liu, Quan, Zhao, Xuezhong, Leng, Jiyan, Li, Ji
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Pyruvate Dehydrogenase Deletion Enhances Effects of Heart Ischemia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914805/
https://ncbi.nlm.nih.gov/pubmed/26884059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw035
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