Dichloroacetate Ameliorates Cardiac Dysfunction Caused by Ischemic Insults Through AMPK Signal Pathway—Not Only Shifts Metabolism

Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK), regulates substrate metabolism in the heart. AMP-activated protein kinase (AMPK) is an age-related energy sensor that protects the heart from ischemic injury. This study aims to investigate whether DCA can protect the heart...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Toxicol Sci
Egile Nagusiak: Li, Xuan, Liu, Jia, Hu, Haiyan, Lu, Shaoxin, Lu, Qingguo, Quan, Nanhu, Rousselle, Thomas, Patel, Mulchand S, Li, Ji
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2019
Gaiak:
Dichloroacetate Effects on Ischemia-Induced Cardiac Dysfunction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358266/
https://ncbi.nlm.nih.gov/pubmed/30371859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy272
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