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A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data

BACKGROUND: Detailed modelling of the neutral mutational process in cancer cells is crucial for identifying driver mutations and understanding the mutational mechanisms that act during cancer development. The neutral mutational process is very complex: whole-genome analyses have revealed that the mu...

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Vydáno v:BMC Bioinformatics
Hlavní autoři: Bertl, Johanna, Guo, Qianyun, Juul, Malene, Besenbacher, Søren, Nielsen, Morten Muhlig, Hornshøj, Henrik, Pedersen, Jakob Skou, Hobolth, Asger
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5909259/
https://ncbi.nlm.nih.gov/pubmed/29673314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-018-2141-2
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