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Non-coding cancer driver candidates identified with a sample- and position-specific model of the somatic mutation rate
Non-coding mutations may drive cancer development. Statistical detection of non-coding driver regions is challenged by a varying mutation rate and uncertainty of functional impact. Here, we develop a statistically founded non-coding driver-detection method, ncdDetect, which includes sample-specific...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5440169/ https://ncbi.nlm.nih.gov/pubmed/28362259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.21778 |
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