Development of a quantitative pharmacodynamic assay for apoptosis in fixed tumor tissue and its application in distinguishing cytotoxic drug—induced DNA double strand breaks from DNA double strand breaks associated with apoptosis

DNA double strand breaks (DSBs) induced by cancer therapeutic agents can lead to DNA damage repair or persistent DNA damage, which can induce apoptotic cell death; however, apoptosis also induces DSBs independent of genotoxic insult. γH2AX is an established biomarker for DSBs but cannot distinguish...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Dull, Angie B., Wilsker, Deborah, Hollingshead, Melinda, Mazcko, Christina, Annunziata, Christina M., LeBlanc, Amy K., Doroshow, James H., Kinders, Robert J., Parchment, Ralph E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908309/
https://ncbi.nlm.nih.gov/pubmed/29682208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24936
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