A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia

Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is one of the most common genetic lesions in acute myeloid leukemia patients (AML). Although FLT3 tyrosine kinase inhibitors initially exhibit clinical activity, resistance to treatment inevitably occurs within months. PIM kinases are...

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Pubblicato in:Oncotarget
Autori principali: Czardybon, Wojciech, Windak, Renata, Gołas, Aniela, Gałęzowski, Michał, Sabiniarz, Aleksandra, Dolata, Izabela, Salwińska, Magdalena, Guzik, Paweł, Zawadzka, Magdalena, Gabor-Worwa, Ewelina, Winnik, Bożena, Żurawska, Małgorzata, Kolasińska, Ewa, Wincza, Ewelina, Bugaj, Marta, Danielewicz, Monika, Majewska, Eliza, Mazan, Milena, Dubin, Grzegorz, Noyszewska-Kania, Monika, Jabłońska, Ewa, Szydłowski, Maciej, Sewastianik, Tomasz, Puła, Bartosz, Szumera-Ciećkiewicz, Anna, Prochorec-Sobieszek, Monika, Mądro, Elżbieta, Lech-Marańda, Ewa, Warzocha, Krzysztof, Tamburini, Jerome, Juszczyński, Przemysław, Brzózka, Krzysztof
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908295/
https://ncbi.nlm.nih.gov/pubmed/29682194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24747
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