Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer

Somatic copy number alterations play a critical role in oncogenesis. Loss of chromosomal regions containing tumor suppressors can lead to collateral deletion of passenger genes. This can be exploited therapeutically if synthetic lethal partners of such passenger genes are known and represent druggab...

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Publicado no:EMBO Mol Med
Main Authors: Szymańska, Ewelina, Nowak, Paulina, Kolmus, Krzysztof, Cybulska, Magdalena, Goryca, Krzysztof, Derezińska‐Wołek, Edyta, Szumera‐Ciećkiewicz, Anna, Brewińska‐Olchowik, Marta, Grochowska, Aleksandra, Piwocka, Katarzyna, Prochorec‐Sobieszek, Monika, Mikula, Michał, Miączyńska, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7005644/
https://ncbi.nlm.nih.gov/pubmed/31930723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910812
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