The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion

AXL, a member of the TAM (TYRO3, AXL, MER) receptor tyrosine kinase family, and its ligand, GAS6, are implicated in oncogenesis and metastasis of many cancer types. However, the exact cellular processes activated by GAS6-AXL remain largely unexplored. Here, we identified an interactome of AXL and re...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zdżalik-Bielecka, Daria, Poświata, Agata, Kozik, Kamila, Jastrzębski, Kamil, Schink, Kay Oliver, Brewińska-Olchowik, Marta, Piwocka, Katarzyna, Stenmark, Harald, Miączyńska, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8285903/
https://ncbi.nlm.nih.gov/pubmed/34244439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024596118
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