Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR crosslinking, CD40 stimula...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Białopiotrowicz, Emilia, Górniak, Patryk, Noyszewska‐Kania, Monika, Puła, Bartosz, Makuch‐Łasica, Hanna, Nowak, Grażyna, Bluszcz, Aleksandra, Szydłowski, Maciej, Jabłonska, Ewa, Piechna, Karolina, Sewastianik, Tomasz, Polak, Anna, Lech‐Marańda, Ewa, Budziszewska, Bożena K., Wasylecka‐Juszczyńska, Maja, Borg, Katarzyna, Warzocha, Krzysztof, Czardybon, Wojciech, Gałęzowski, Michał, Windak, Renata, Brzózka, Krzysztof, Juszczyński, Przemysław
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010703/
https://ncbi.nlm.nih.gov/pubmed/29665227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13632
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