MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy

Resistance to glucocorticosteroids (GCs) is a major adverse prognostic factor in B-ALL, but the molecular mechanisms leading to GC resistance are not completely understood. Herein, we sought to elucidate the molecular background of GC resistance in B-ALL and characterize the therapeutic potential of...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Polak, Anna, Kiliszek, Przemysław, Sewastianik, Tomasz, Szydłowski, Maciej, Jabłońska, Ewa, Białopiotrowicz, Emilia, Górniak, Patryk, Markowicz, Sergiusz, Nowak, Eliza, Grygorowicz, Monika A., Prochorec-Sobieszek, Monika, Nowis, Dominika, Gołąb, Jakub, Giebel, Sebastian, Lech-Marańda, Ewa, Warzocha, Krzysztof, Juszczyński, Przemysław
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4872998/
https://ncbi.nlm.nih.gov/pubmed/27196001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155893
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados