Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR crosslinking, CD40 stimula...

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Publicat a:J Cell Mol Med
Autors principals: Białopiotrowicz, Emilia, Górniak, Patryk, Noyszewska‐Kania, Monika, Puła, Bartosz, Makuch‐Łasica, Hanna, Nowak, Grażyna, Bluszcz, Aleksandra, Szydłowski, Maciej, Jabłonska, Ewa, Piechna, Karolina, Sewastianik, Tomasz, Polak, Anna, Lech‐Marańda, Ewa, Budziszewska, Bożena K., Wasylecka‐Juszczyńska, Maja, Borg, Katarzyna, Warzocha, Krzysztof, Czardybon, Wojciech, Gałęzowski, Michał, Windak, Renata, Brzózka, Krzysztof, Juszczyński, Przemysław
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010703/
https://ncbi.nlm.nih.gov/pubmed/29665227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13632
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