Improved therapy for medulloblastoma: targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy

Aberrant activation and interactions of hedgehog (HH) and PI3K/AKT/mTOR signaling pathways are frequently associated with high-risk medulloblastoma (MB). Thus, combined targeting of the HH and PI3K/AKT/mTOR pathways could be a viable therapeutic strategy to treat high-risk patients. Therefore, we in...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Chaturvedi, Nagendra K., Kling, Matthew J., Coulter, Don W., McGuire, Timothy R., Ray, Sutapa, Kesherwani, Varun, Joshi, Shantaram S., Sharp, J. Graham
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908274/
https://ncbi.nlm.nih.gov/pubmed/29682173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24618
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