The Identification of Inhibitory Compounds of Rickettsia prowazekii Methionine Aminopeptidase for Antibacterial Applications

Methionine aminopeptidase (MetAP) is a dinuclear metallo-protease responsible for the cleavage of methionine initiator residues from nascent proteins. MetAP activity is necessary for bacterial proliferation and is therefore a projected novel antibacterial target. A compound library consisting of 294...

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Publicado no:Bioorg Med Chem Lett
Main Authors: Helgren, Travis R., Seven, Elif S., Chen, Congling, Edwards, Thomas E., Staker, Bart L., Abendroth, Jan, Myler, Peter J., Horn, James R., Hagen, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5908248/
https://ncbi.nlm.nih.gov/pubmed/29551481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.03.002
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