Variable Domain N-Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability

Immunoglobulin G (IgG) can contain N-linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the C(H)2 domains. These Fab glycans are acquired following introduction of N-glycosylation sites during somatic hypermutation and contribute to antibody diversifi...

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Udgivet i:Front Immunol
Main Authors: van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., van Breemen, Mariëlle J., de Taeye, Steven W., Ooijevaar-de Heer, Pleuni, Sanders, Rogier W., Rispens, Theo
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906590/
https://ncbi.nlm.nih.gov/pubmed/29706962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00740
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