Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region

A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually defined in terms of amino acid composition. However, variable domains may also acquire N-linked glycans, a process conditional on the introduct...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., Ooijevaar-de Heer, Pleuni, van Schie, Karin A., Kruithof, Simone, Berkowska, Magdalena A., van der Schoot, C. Ellen, IJspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E. M., Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828577/
https://ncbi.nlm.nih.gov/pubmed/29432186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711720115
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