Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region

A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually defined in terms of amino acid composition. However, variable domains may also acquire N-linked glycans, a process conditional on the introduct...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., Ooijevaar-de Heer, Pleuni, van Schie, Karin A., Kruithof, Simone, Berkowska, Magdalena A., van der Schoot, C. Ellen, IJspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E. M., Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5828577/
https://ncbi.nlm.nih.gov/pubmed/29432186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711720115
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki