TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain

Although TRPV1 channels represent a key player of noxious heat sensation, the precise mechanisms for thermal hyperalgesia remain unknown. We report here that conditional knockout of deSUMOylation enzyme, SENP1, in mouse dorsal root ganglion (DRG) neurons exacerbated thermal hyperalgesia in both carr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Wang, Yan, Gao, Yingwei, Tian, Quan, Deng, Qi, Wang, Yangbo, Zhou, Tian, Liu, Qiang, Mei, Kaidi, Wang, Yingping, Liu, Huiqing, Ma, Ruining, Ding, Yuqiang, Rong, Weifang, Cheng, Jinke, Yao, Jing, Xu, Tian-Le, Zhu, Michael X., Li, Yong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906468/
https://ncbi.nlm.nih.gov/pubmed/29670121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03974-7
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