DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation

Imbalanced mitochondrial fission/fusion, a major cause of apoptotic cell death, often results from dysregulation of Drp1 phosphorylation of two serines, S616 and S637. Whereas kinases for Drp1-S616 phosphorylation are well-described, phosphatase(s) for its dephosphorylation remains unclear. Here, we...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Ma, Ruining, Ma, Lina, Weng, Weiji, Wang, Yingping, Liu, Huiqing, Guo, Rongjun, Gao, Yingwei, Tu, Jun, Xu, Tian-Le, Cheng, Jinke, Zhu, Michael X., Zhou, Aiwu, Li, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7096176/
https://ncbi.nlm.nih.gov/pubmed/32232156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz0361
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