TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain

Although TRPV1 channels represent a key player of noxious heat sensation, the precise mechanisms for thermal hyperalgesia remain unknown. We report here that conditional knockout of deSUMOylation enzyme, SENP1, in mouse dorsal root ganglion (DRG) neurons exacerbated thermal hyperalgesia in both carr...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Wang, Yan, Gao, Yingwei, Tian, Quan, Deng, Qi, Wang, Yangbo, Zhou, Tian, Liu, Qiang, Mei, Kaidi, Wang, Yingping, Liu, Huiqing, Ma, Ruining, Ding, Yuqiang, Rong, Weifang, Cheng, Jinke, Yao, Jing, Xu, Tian-Le, Zhu, Michael X., Li, Yong
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906468/
https://ncbi.nlm.nih.gov/pubmed/29670121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03974-7
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