TRPV1 SUMOylation regulates nociceptive signaling in models of inflammatory pain

Although TRPV1 channels represent a key player of noxious heat sensation, the precise mechanisms for thermal hyperalgesia remain unknown. We report here that conditional knockout of deSUMOylation enzyme, SENP1, in mouse dorsal root ganglion (DRG) neurons exacerbated thermal hyperalgesia in both carr...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wang, Yan, Gao, Yingwei, Tian, Quan, Deng, Qi, Wang, Yangbo, Zhou, Tian, Liu, Qiang, Mei, Kaidi, Wang, Yingping, Liu, Huiqing, Ma, Ruining, Ding, Yuqiang, Rong, Weifang, Cheng, Jinke, Yao, Jing, Xu, Tian-Le, Zhu, Michael X., Li, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5906468/
https://ncbi.nlm.nih.gov/pubmed/29670121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03974-7
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