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Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane
The transient receptor potential vanilloid-1 (TRPV1) ion channel is essential for sensation of thermal and chemical pain. TRPV1 activation is accompanied by Ca(2+)-dependent desensitization; acute desensitization reflects rapid reduction in channel activity during stimulation, whereas tachyphylaxis...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6421460/ https://ncbi.nlm.nih.gov/pubmed/30804201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819635116 |
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