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Flexibility vs Preorganization: Direct Comparison of Binding Kinetics for a Disordered Peptide and Its Exact Preorganized Analogues
Many intrinsically disordered proteins, which are prevalent in nature, fold only upon binding their structured partner proteins. Such proteins have been hypothesized to have a kinetic advantage over their folded, preorganized analogues in binding their partner proteins. Here we determined the effect...
Uloženo v:
| Vydáno v: | J Phys Chem B |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5903555/ https://ncbi.nlm.nih.gov/pubmed/28992700 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b08486 |
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