An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity

Paraquat (1,1′-dimethyl, 4,4′-bipyridinium dichloride; PQ), a widely used herbicide, is toxic to mammals through ingestion, inhalation and skin contact. Epidemiological data suggest that PQ is also mutagenic and carcinogenic, especially in high doses. The toxic and mutagenic properties of PQ are att...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Free Radic Biol Med
Egile Nagusiak: Tajai, Preechaya, Fedeles, Bogdan I., Suriyo, Tawit, Navasumrit, Panida, Kanitwithayanun, Jantamas, Essigmann, John M., Satayavivad, Jutamaad
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902796/
https://ncbi.nlm.nih.gov/pubmed/29289706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.12.035
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