Phosphorylation of human oxoguanine DNA glycosylase (α-OGG1) modulates its function

Oxoguanine DNA glycosylase (OGG1) initiates the repair of 8-oxoguanine (8-oxoG), a major oxidative DNA base modification that has been directly implicated in cancer and aging. OGG1 functions in the base excision repair pathway, for which a molecular hand-off mechanism has been proposed. To date, onl...

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Hauptverfasser: Hu, Jingping, Imam, Syed Z., Hashiguchi, Kazunari, de Souza-Pinto, Nadja C., Bohr, Vilhelm A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1143695/
https://ncbi.nlm.nih.gov/pubmed/15942030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki636
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