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Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions
7,8-Dihydro-8-oxoguanine DNA glycosylase (OGG1) is a major DNA glycosylase involved in base-excision repair (BER) of oxidative DNA damage to nuclear and mitochondrial DNA (mtDNA). We used OGG1-deficient (OGG1(−/−)) mice to examine the possible roles of OGG1 in the vulnerability of neurons to ischemi...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049522/ https://ncbi.nlm.nih.gov/pubmed/20736962 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.147 |
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