Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions

7,8-Dihydro-8-oxoguanine DNA glycosylase (OGG1) is a major DNA glycosylase involved in base-excision repair (BER) of oxidative DNA damage to nuclear and mitochondrial DNA (mtDNA). We used OGG1-deficient (OGG1(−/−)) mice to examine the possible roles of OGG1 in the vulnerability of neurons to ischemi...

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Bibliografiske detaljer
Main Authors: Liu, Dong, Croteau, Deborah L, Souza-Pinto, Nadja, Pitta, Michael, Tian, Jingyan, Wu, Christopher, Jiang, Haiyang, Mustafa, Khadija, Keijzers, Guido, Bohr, Vilhelm A, Mattson, Mark P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049522/
https://ncbi.nlm.nih.gov/pubmed/20736962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2010.147
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