Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer’s disease (AD), the underlying mechanism remains to be explored. Here we demonstrate that neurons in the brains of patients with AD and AD mice show reduction of sphingosine kinase1...

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I publikationen:Nat Commun
Huvudupphovsmän: Lee, Ju Youn, Han, Seung Hoon, Park, Min Hee, Baek, Bosung, Song, Im-Sook, Choi, Min-Koo, Takuwa, Yoh, Ryu, Hoon, Kim, Seung Hyun, He, Xingxuan, Schuchman, Edward H., Bae, Jae-Sung, Jin, Hee Kyung
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902554/
https://ncbi.nlm.nih.gov/pubmed/29662056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03674-2
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