Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (SphK) activity is reduced in NP–C patient fibroblasts and NP–C mouse Purkinje neurons (PNs)...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Edward H., Bae, Jae-sung, Jin, Hee Kyung
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263144/
https://ncbi.nlm.nih.gov/pubmed/25417698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6514
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