EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition

Expression of EGFRvIII is frequently observed in glioblastoma and is associated with increased cellular proliferation, enhanced tolerance to metabolic stresses, accelerated tumor growth, therapy resistance and poor prognosis. We observed that expression of EGFRvIII elevates the activation of macroau...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Jutten, Barry, Keulers, Tom G., Peeters, Hanneke J. M., Schaaf, Marco B. E., Savelkouls, Kim G. M., Compter, Inge, Clarijs, Ruud, Schijns, Olaf E. M. G., Ackermans, Linda, Teernstra, Onno P. M., Zonneveld, Marijke I., Colaris, Resi M. E., Dubois, Ludwig, Vooijs, Marc A., Bussink, Johan, Sotelo, Julio, Theys, Jan, Lammering, Guido, Rouschop, Kasper M. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Papers - Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5902239/
https://ncbi.nlm.nih.gov/pubmed/29377763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1409926
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