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Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx

The two-pore-domain potassium (K2P) channel TREK-2 serves to modulate plasma membrane potential in dorsal root ganglia c-fiber nociceptors, which tunes electrical excitability and nociception. Thus, TREK-2 channels are considered a potential therapeutic target for treating pain; however, there are c...

詳細記述

保存先:
書誌詳細
出版年:ACS Chem Neurosci
主要な著者: Dadi, Prasanna K., Vierra, Nicholas C., Days, Emily, Dickerson, Matthew T., Vinson, Paige N., Weaver, C. David, Jacobson, David A
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5901755/
https://ncbi.nlm.nih.gov/pubmed/27805811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00301
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