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Cell-Permeable, Small-Molecule Activators of the Insulin-Degrading Enzyme
The insulin-degrading enzyme (IDE) cleaves numerous small peptides, including biologically active hormones and disease-related peptides. The propensity of IDE to degrade neurotoxic Aβ peptides marks IDE as a potential therapeutic target for Alzheimer disease. Using a synthetic reporter based on the...
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| 出版年: | J Biomol Screen |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5901702/ https://ncbi.nlm.nih.gov/pubmed/22740246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057112451921 |
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