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Small-Molecule Inhibitors of the Rce1p CaaX Protease

The Rce1p protease is required for the maturation of the Ras GTPase and certain other isoprenylated proteins and is considered a chemotherapeutic target. To identify new small-molecule inhibitors of Rce1p, the authors screened the National Cancer Institute Diversity Set compound library using in vit...

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Main Authors: Manandhar, Surya P., Hildebrandt, Emily R., Schmidt, Walter K.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173876/
https://ncbi.nlm.nih.gov/pubmed/17942791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057107307226
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