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Chemical inhibition of CaaX protease activity disrupts yeast Ras localization
Proteins possessing a C-terminal CaaX motif, such as the Ras GTPases, undergo extensive post-translational modification that includes attachment of an isoprenoid lipid, proteolytic processing and carboxylmethylation. Inhibition of the enzymes involved in these processes is considered a cancer-therap...
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| Publicado no: | Yeast |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5871226/ https://ncbi.nlm.nih.gov/pubmed/20162532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/yea.1756 |
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