Llwytho...

Chemical inhibition of CaaX protease activity disrupts yeast Ras localization

Proteins possessing a C-terminal CaaX motif, such as the Ras GTPases, undergo extensive post-translational modification that includes attachment of an isoprenoid lipid, proteolytic processing and carboxylmethylation. Inhibition of the enzymes involved in these processes is considered a cancer-therap...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Yeast
Prif Awduron: Manandhar, Surya P., Hildebrandt, Emily R., Jacobsen, William H., Santangelo, George M., Schmidt, Walter K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871226/
https://ncbi.nlm.nih.gov/pubmed/20162532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/yea.1756
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