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Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides
The stress sensors ATF6, IRE1, and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to re-establish proteostasis. UPR have been extensively investigat...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5900776/ https://ncbi.nlm.nih.gov/pubmed/29453283 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001484 |
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