Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides

The stress sensors ATF6, IRE1, and PERK monitor deviations from homeostatic conditions in the endoplasmic reticulum (ER), a protein biogenesis compartment of eukaryotic cells. Their activation elicits unfolded protein responses (UPR) to re-establish proteostasis. UPR have been extensively investigat...

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Vydáno v:J Biol Chem
Hlavní autoři: Bergmann, Timothy J., Fregno, Ilaria, Fumagalli, Fiorenza, Rinaldi, Andrea, Bertoni, Francesco, Boersema, Paul J., Picotti, Paola, Molinari, Maurizio
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900776/
https://ncbi.nlm.nih.gov/pubmed/29453283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001484
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