Site-specific polyubiquitination differentially regulates parathyroid hormone receptor–initiated MAPK signaling and cell proliferation

G protein–coupled receptor (GPCR) signaling and trafficking are essential for cellular function and regulated by phosphorylation, β-arrestin, and ubiquitination. The GPCR parathyroid hormone receptor (PTHR) exhibits time-dependent reversible ubiquitination. The exact ubiquitination sites in PTHR are...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Zhang, Qiangmin, Xiao, Kunhong, Liu, Hongda, Song, Lei, McGarvey, Jennifer C., Sneddon, W. Bruce, Bisello, Alessandro, Friedman, Peter A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900769/
https://ncbi.nlm.nih.gov/pubmed/29444827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.001737
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