Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore

The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(−) channel that apparently has evolved from an ancestral active transporter. Key to the CFTR's switch from pump to channel function may have been the appearance of one or more “lateral portals.” Such portals connect the cyto...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Li, Man-Song, Cowley, Elizabeth A., El Hiani, Yassine, Linsdell, Paul
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Membrane Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900759/
https://ncbi.nlm.nih.gov/pubmed/29475947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001373
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