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Functional organization of cytoplasmic portals controlling access to the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel pore

The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl(−) channel that apparently has evolved from an ancestral active transporter. Key to the CFTR's switch from pump to channel function may have been the appearance of one or more “lateral portals.” Such portals connect the cyto...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Li, Man-Song, Cowley, Elizabeth A., El Hiani, Yassine, Linsdell, Paul
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900759/
https://ncbi.nlm.nih.gov/pubmed/29475947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001373
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