High dietary fat and sucrose result in an extensive and time-dependent deterioration in health of multiple physiological systems in mice

Obesity is associated with metabolic dysfunction, including insulin resistance and hyperinsulinemia, and with disorders such as cardiovascular disease, osteoporosis, and neurodegeneration. Typically, these pathologies are examined in discrete model systems and with limited temporal resolution, and w...

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Pubblicato in:J Biol Chem
Autori principali: Burchfield, James G., Kebede, Melkam A., Meoli, Christopher C., Stöckli, Jacqueline, Whitworth, P. Tess, Wright, Amanda L., Hoffman, Nolan J., Minard, Annabel Y., Ma, Xiuquan, Krycer, James R., Nelson, Marin E., Tan, Shi-Xiong, Yau, Belinda, Thomas, Kristen C., Wee, Natalie K. Y., Khor, Ee-Cheng, Enriquez, Ronaldo F., Vissel, Bryce, Biden, Trevor J., Baldock, Paul A., Hoehn, Kyle L., Cantley, James, Cooney, Gregory J., James, David E., Fazakerley, Daniel J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Metabolism
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900752/
https://ncbi.nlm.nih.gov/pubmed/29440390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000808
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