Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d

N(6)-methyladenosine (m(6)A) is the most abundant mRNA modification in eukaryotes, playing crucial roles in multiple biological processes. m(6)A is catalyzed by the activity of methyltransferase-like 3 (Mettl3), which depends on additional proteins whose precise functions remain poorly understood. H...

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Vydáno v:Genes Dev
Hlavní autoři: Knuckles, Philip, Lence, Tina, Haussmann, Irmgard U., Jacob, Dominik, Kreim, Nastasja, Carl, Sarah H., Masiello, Irene, Hares, Tina, Villaseñor, Rodrigo, Hess, Daniel, Andrade-Navarro, Miguel A., Biggiogera, Marco, Helm, Mark, Soller, Matthias, Bühler, Marc, Roignant, Jean-Yves
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900714/
https://ncbi.nlm.nih.gov/pubmed/29535189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.309146.117
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