The human ZC3H3 and RBM26/27 proteins are critical for PAXT-mediated nuclear RNA decay

Recruitment of the human ribonucleolytic RNA exosome to nuclear polyadenylated (pA(+)) RNA is facilitated by the Poly(A) Tail eXosome Targeting (PAXT) connection. Besides its core dimer, formed by the exosome co-factor MTR4 and the ZFC3H1 protein, the PAXT connection remains poorly defined. By chara...

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Foilsithe in:Nucleic Acids Res
Main Authors: Silla, Toomas, Schmid, Manfred, Dou, Yuhui, Garland, William, Milek, Miha, Imami, Koshi, Johnsen, Dennis, Polak, Patrik, Andersen, Jens S, Selbach, Matthias, Landthaler, Markus, Jensen, Torben Heick
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2020
Ábhair:
Molecular Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049725/
https://ncbi.nlm.nih.gov/pubmed/31950173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1238
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