A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing

X-chromosome inactivation is the process that evolved in mammals to equalize levels of X-linked gene expression in XX females relative to XY males. Silencing of a single X chromosome in female cells is mediated by the non-coding RNA Xist. Although progress has been made toward identifying factors th...

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Publicado no:Cell Rep
Main Authors: Moindrot, Benoit, Cerase, Andrea, Coker, Heather, Masui, Osamu, Grijzenhout, Anne, Pintacuda, Greta, Schermelleh, Lothar, Nesterova, Tatyana B., Brockdorff, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4534822/
https://ncbi.nlm.nih.gov/pubmed/26190105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.06.053
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