An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality

It has been well established that histone and DNA modifications are critical to maintaining the equilibrium between pluripotency and differentiation during early embryogenesis. Mutations in key regulators of DNA methylation have shown that the balance between gene regulation and function is critical...

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Dettagli Bibliografici
Pubblicato in:Genes Dev
Autori principali: Ferrer, Christina M., Alders, Marielle, Postma, Alex V., Park, Seonmi, Klein, Mark A., Cetinbas, Murat, Pajkrt, Eva, Glas, Astrid, van Koningsbruggen, Silvana, Christoffels, Vincent M., Mannens, Marcel M.A.M., Knegt, Lia, Etchegaray, Jean-Pierre, Sadreyev, Ruslan I., Denu, John M., Mostoslavsky, Gustavo, van Maarle, Merel C., Mostoslavsky, Raul
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900711/
https://ncbi.nlm.nih.gov/pubmed/29555651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.307330.117
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