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Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation
The RNA “GAGU” duplex, (5′GACGAGUGUCA)(2), contains the internal loop (5′-GAGU-3′)(2) , which has two conformations in solution as determined by NMR spectroscopy. The major conformation has a loop structure consisting of trans-Watson–Crick/Hoogsteen GG pairs, A residues stacked on each other, U resi...
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| 發表在: | RNA |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Cold Spring Harbor Laboratory Press
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5900564/ https://ncbi.nlm.nih.gov/pubmed/29434035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064527.117 |
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