Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation

The RNA “GAGU” duplex, (5′GACGAGUGUCA)(2), contains the internal loop (5′-GAGU-3′)(2) , which has two conformations in solution as determined by NMR spectroscopy. The major conformation has a loop structure consisting of trans-Watson–Crick/Hoogsteen GG pairs, A residues stacked on each other, U resi...

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Udgivet i:RNA
Main Authors: Spasic, Aleksandar, Kennedy, Scott D., Needham, Laura, Manoharan, Muthiah, Kierzek, Ryszard, Turner, Douglas H., Mathews, David H.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900564/
https://ncbi.nlm.nih.gov/pubmed/29434035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064527.117
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