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Molecular dynamics correctly models the unusual major conformation of the GAGU RNA internal loop and with NMR reveals an unusual minor conformation

The RNA “GAGU” duplex, (5′GACGAGUGUCA)(2), contains the internal loop (5′-GAGU-3′)(2) , which has two conformations in solution as determined by NMR spectroscopy. The major conformation has a loop structure consisting of trans-Watson–Crick/Hoogsteen GG pairs, A residues stacked on each other, U resi...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:RNA
Egile Nagusiak: Spasic, Aleksandar, Kennedy, Scott D., Needham, Laura, Manoharan, Muthiah, Kierzek, Ryszard, Turner, Douglas H., Mathews, David H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900564/
https://ncbi.nlm.nih.gov/pubmed/29434035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.064527.117
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