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Optimization of an AMBER Force Field for the Artificial Nucleic Acid, LNA, and Benchmarking with NMR of L(CAAU)

[Image: see text] Locked Nucleic Acids (LNAs) are RNA analogues with an O2′-C4′ methylene bridge which locks the sugar into a C3′-endo conformation. This enhances hybridization to DNA and RNA, making LNAs useful in microarrays and potential therapeutics. Here, the LNA, L(CAAU), provides a simplified...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Condon, David E., Yildirim, Ilyas, Kennedy, Scott D., Mort, Brendan C., Kierzek, Ryszard, Turner, Douglas H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Chemical Society 2013
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3917691/
https://ncbi.nlm.nih.gov/pubmed/24377321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp408909t
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