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Revision of AMBER Torsional Parameters for RNA Improves Free Energy Predictions for Tetramer Duplexes with GC and iGiC Base Pairs

All-atom force fields are important for predicting thermodynamic, structural, and dynamic properties of RNA. In this paper, results are reported for thermodynamic integration calculations of free energy differences of duplex formation when CG pairs in the RNA duplexes r(CCGG)(2), r(GGCC)(2), r(GCGC)...

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Autori principali: Yildirim, Ilyas, Kennedy, Scott D., Stern, Harry A., Hart, James M., Kierzek, Ryszard, Turner, Douglas H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2011
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254190/
https://ncbi.nlm.nih.gov/pubmed/22249447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct200557r
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